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Alpha-thalassemia

Studies from Chiang Mai University further understanding of alpha-thalassemia

Published in Blood Weekly, June 26th, 2008

"alpha-Thalassemia-1 Southeast Asian (SEA) type is the most common genetic disorder in the Asian population. Couples who are both carriers have a 25% chance of conceiving Bart's hydrops fetalis," scientists in Chiang Mai, Thailand report.

"Therefore, results from carrier screening and prenatal diagnosis frequently need to be available rapidly. A rapid technique for diagnosis of alpha-thalassemia-1 SEA type was implemented. The technique used is based on real-time gap-PCR and high resolution melting (HRM) analysis of the amplified fragment using the Rotor-Gene 6000 (TM). The DNA samples used for amplification were obtained from whole blood, cord blood, and chorionic...

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