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Tufts University, Health Sciences

The APCs of nerve cell function

Published in Blood Weekly, July 3rd, 2008

BOSTON (June 16, 2008) — Rapid information processing in the nervous system requires synapses, specialized contact sites between nerve cells and their targets. One particular synapse type, cholinergic, uses the chemical transmitter acetylcholine to communicate between nerve cells. Cholinergic synapses are essential for normal learning and memory, arousal, attention, and all autonomic (involuntary) nervous system functions. Malfunction of cholinergic synapses is implicated in Alzheimer's disease, age-related hearing loss, autonomic neuropathies, and certain forms of epilepsy and schizophrenia. Despite the importance of cholinergic synapses for cognitive and autonomic functions, little is...

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