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Acute Promyelocytic Leukemia

Research on acute promyelocytic leukemia detailed by scientists at Princess Margaret Hospital

Published in Blood Weekly, July 3rd, 2008

"The case of a patient who developed acute renal failure, gastrointestinal bleeding, and cardiac arrhythmia after receiving arsenic trioxide for the treatment of acute promyelocytic leukemia (APL) is described. An 84-year-old Caucasian woman with a history of osteoarthritis sought medical attention for relapse of her APL, which had initially been diagnosed approximately 30 months earlier," investigators in Toronto, Canada report.

"Complete remission was accomplished with three cycles of i.v. daunorubicin for 3 days and oral tretinoin for 28 days. After 19 months in remission, she was noted to have increased bruising and blood test values consistent with APL relapse. Two...

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