DNA Research

Research from Mayo Clinic yields new data on DNA research

Published in Blood Weekly, July 24th, 2008

"The proteasome is a multisubunit cellular organelle that functions as a nonlysosomal threonine protease. Proleasomes play a critical role in the degradation of proteins, regulating a variety of cellular processes, and they are also the target for antineoplastic proteasome inhibitors," investigators in the United States report.

"Genetic variation in proteasome subunits could influence both proteasome function and response to drug therapy. We resequenced genes encoding the three active proteasome 0 subunits using 240 DNA samples from four ethnic groups and the beta 5 subunit gene in 79 DNA samples from multiple myeloma patients who had been treated with the proteasome...

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Source: Blood Weekly (2008-07-24)

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