Stem Cell Research

Researchers from Harvard University detail new studies and findings in the area of stem cell research

Published in Blood Weekly, July 31st, 2008

"Pluripotency of embryonic stem (ES) cells is maintained by transcription factors that form a highly interconnected protein interaction network surrounding the homeobox protein Nanog. Enforced expression of Nanog in mouse ES (mES) cells promotes self-renewal and alleviates their requirement for leukemia inhibitory factor (LIF)," scientists in the United States report.

"Understanding molecular mechanisms by which Nanog functions should illuminate fundamental properties of stem cells and the process of cellular reprogramming. Previously, we showed that Nanog forms multiple protein complexes in mES cells. Here, we demonstrate that Nanog dimerizes through its C-terminal...

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Source: Blood Weekly (2008-07-31)

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