Chronic Heart Failure
Researchers at Sahlgrenska University have published new data on chronic heart failure
Published in Blood Weekly, August 7th, 2008
According to recent research from Gothenburg, Sweden, "Patients with chronic heart failure (CHF) often require higher doses of nitroglycerin (glyceryl trinitrate, GTN) than patients with normal cardiac function to achieve a given haemodynamic goal. Two pathways leading to biotransformation of GTN have been characterized; a high-affinity pathway operative in nanomolar concentration ranges yielding predominantly 1,2-glyceryl dinitrate (1,2-GDN), and a low-affinity pathway operative at higher, micromolar concentrations of GTN associated with a greater proportion of 1,3-GDN formation."
"We tested the hypothesis that, at a given GTN-induced blood pressure reduction, the CHF...
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Source: Blood Weekly (2008-08-07)
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