Apoptosis

Research findings from W. Pickering et al update understanding of apoptosis

Published in Blood Weekly, August 7th, 2008

"Coagulation has an absolute requirement for macromolecular complexes to be assembled on a negatively charged phospholipid (PL) surface. Previously, we reported that malignant T-lymphoblastoid cells have the ability to support procoagulant activity (PCA) independently of tissue factor by providing such a surface," researchers in Potters Bar, the United Kingdom report.

"To explore the effect of two pathophysiologic processes, apoptosis and lipid peroxidation (LP), on this PL-dependent PCA. Three different assays for PL-dependent PCA (factor IXa-initiated FXa and thrombin generation and prothrombinase activity) were used to investigate this PCA after exposing three...

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Source: Blood Weekly (2008-08-07)

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