Primary Hyperoxaluria
New primary hyperoxaluria study findings recently were reported by researchers at College of Medicine
Published in Blood Weekly, August 14th, 2008
According to a study from the United States, "Primary hyperoxaluria type-1 (PH1) is an autosomal recessive disease characterized by excessive oxalate production by hepatocytes caused by the deficiency of peroxisomal alanine-glyoxylate aminotransferase (AGT) activity. Persistent hyperoxaluria causes nephrocalcitiosis and urolithiasis, leading to renal failure, followed by tissue oxalosis with life-threatening complications."
"Combined liver-kidney transplantation is the only definitive treatment of PHI. Hepatocyte transplantation, which is much less invasive, could have offered an attractive alternative. However, because the AGT-deficient hepatocytes overproduce oxalate,...
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Source: Blood Weekly (2008-08-14)
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