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Hyperhomocysteinemia

Studies from A.P. Singh et al add new findings in the area of hyperhomocysteinemia

Published in Blood Weekly, August 21st, 2008

According to a study from India, "The present study has been designed to investigate the effect of sodium cromoglyeate and ketotifen, mast cell stabilizers in hyperhomocystememia-induced cardiac hypertrophy in rats. Rats were administered L-methionine (1.7 g/kg/day PO) for 8 weeks to produce hyperhomocysteinemia."

"Sodium cromoglycate (24 mg/kg/day IP) and ketotifen (1mg/kg/day IP) treatments were started from first day of administration of L-methionine and continued for 8 weeks. The development of cardiac hypertrophy was assessed in terms of measuring mean arterial blood pressure (MABP), ratio of left ventricular (LV) weight to body weight (LVW/BW), LV wall thickness...

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