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Acute Promyelocytic Leukemia

Studies conducted at S.J. Collins et al on acute promyelocytic leukemia recently published

Published in Blood Weekly, August 21st, 2008

"Purpose of review All-trans retinoic acid therapy of acute promyelocytic leukemia represents the most successful example of differentiation-induction therapy in clinical oncology. However, acute promyelocytic leukemia represents only a small minority (10-15%) of the myeloid leukemias," scientists in the United States report.

"Recent studies provide significant insight into why some myeloid leukemias respond dramatically to all-trans retinoic acid mediated differentiation therapy, whereas others do not. Recent findings Utilizing in-vitro experimental models of all-trans retinoic acid triggered myeloid leukemia differentiation, specific genes that are important...

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