Ischemia
New ischemia findings from Wuhan University described
Published in Blood Weekly, September 4th, 2008
According to recent research from Wuhan, People's Republic of China, "We examined whether nuclear factor-kappa B (NF-kappa B) activation was involved in the ischemia-reperfusion (I/R) injury in a rat skin flap model and whether administration of pyrrolidine dithiocarbamate (PDTC), a NF-kappa B inhibitor, could improve flap viability. Eighty-four Sprague-Dawley rats were divided into control group (n = 28), I/R group (n = 28), and PDTC-treated group (n = 28)."
"An abdominal skin flap (4 x 5 cm) was elevated and subjected to 10 hours of ischemia in both the I/R group and the PDTC-treated group. A bolus of PDTC (300 mg/kg) was infused 5 minutes before reperfusion, followed...
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Source: Blood Weekly (2008-09-04)
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