Life Sciences
Reports from Eindhoven University of Technology, Department of Biomedical Engineering advance knowledge in life sciences
Published in Blood Weekly, September 4th, 2008
Current study results from the report, 'His-tags as Zn(II) binding motifs in a protein-based fluorescent sensor,' have been published. "Fluorescent indicators that allow real-time imaging of Zn(II) in living cells are invaluable tools for understanding Zn(II) homeostasis. Genetically encoded sensors based on fluorescence resonance energy transfer between fluorescent protein domains have important advantages over synthetic probes," scientists in Netherlands report.
"We discovered that hexahistidine tags have a strong tendency to dimerize upon binding of Zn(II) in solution and we used this principle to develop a new protein-based sensor for Zn(II). Enhanced cyan and...
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Source: Blood Weekly (2008-09-04)
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