Apoptosis

Scientists at Shandong University target apoptosis

Published in Blood Weekly, September 4th, 2008

"Ouabain is Na+/K+ ATPase inhibitor and an endogenous regulator of blood pressure, it has dual effect on vascular endothelial cells(VEC) cell growth and VEC apoptosis is contributed to vascular dysfunction involved in vascular remolding. However, the precise mechanisms of apoptosis induced by ouabain remained unclear," investigators in Jinan, People's Republic of China report.

"The objective of this study was to identify the differently expressed proteins involved in VEC apoptosis induced by ouabain in order to explore cellular and subcellular mechanisms related to ouabain actions. Human umbilical vein endothelial cells (HUVEC) were exposed to increasing concentrations...

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Source: Blood Weekly (2008-09-04)

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