Prothrombin
Research results from University of Toronto, Toronto General Research Institute update understanding of prothrombin
Published in Blood Weekly, September 11th, 2008
Data detailed in 'LPS-induced murine abortions require C5 but not C3, and are prevented by upregulating expression of the CD200 tolerance signaling molecule' have been presented. According to recent research from Toronto, Canada, "PROBLEM: Lipopolysaccharide (LPS) acts via tlr4 to promote Th1 cytokine secretion and abortions. LPS is an essential co-factor in spontaneous abortion in the CBA x DBA/2 model and in stress-triggered abortions."
"In the CBA x DBA/2 model, C3a, C5a, and fgl2 prothrombinase participate in triggering inflammation that terminates embryo viability. As fgl2 prothrombinase (via thrombin) can generate C5a, it was predicted that LPS-driven abortions...
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Source: Blood Weekly (2008-09-11)
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