Tissue Engineering
New data from E.C. Raulfs et al illuminate research in tissue engineering
Published in Blood Weekly, September 25th, 2008
According to recent research from the United States, "It has been proposed that iron-sulfur [Fe-S] clusters destined for the maturation of [Fe-S] proteins can be preassembled on a molecular scaffold designated IscU. In the present article, it is shown that production of the intact Azotobacter vinelandii [Fe-S] cluster biosynthetic machinery at levels exceeding the amount required for cellular maturation of [Fe-S] proteins results in the accumulation of: (i) apo-IscU, (ii) an oxygen-labile [2Fe-2S] cluster-loaded form of IscU, and (iii) IscU complexed with the S-delivery protein, IscS."
"It is suggested that these species represent different stages of the [Fe-S] cluster...
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Source: Blood Weekly (2008-09-25)
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