Mantle Cell Lymphoma Therapy
Research from University of Texas, M.D. Anderson Cancer Center in mantle cell lymphoma therapy provides new insights
Published in Blood Weekly, September 25th, 2008
Research findings, 'Inhibition of the p53 E3 ligase HDM-2 induces apoptosis and DNA damage--independent p53 phosphorylation in mantle cell lymphoma,' are discussed in a new report. According to a study from the United States, "The ubiquitin-proteasome pathway has been validated as a target in non-Hodgkin's lymphoma through demonstration of the activity of the proteasome inhibitor bortezomib. Another potentially attractive target is the human homologue of the murine double minute-2 protein, HDM-2, which serves as the major p53 E3 ubiquitin ligase; we therefore evaluated the activity of a novel agent, MI-63, which disrupts the HDM-2/p53 interaction."
"Treatment of...
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Source: Blood Weekly (2008-09-25)
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