Community-Acquired

New community-acquired research from M.I. Garcialaorden and co-researchers described

Published in Blood Weekly, September 25th, 2008

According to recent research from Spain, "Community-acquired pneumonia (CAP) is the leading cause of death from infection in developed countries. Mannose-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) deficiencies are common primary immunodeficiencies the clinical penetrance of which remains controversial."

"MBL is a serum lectin that mediates phagocytosis and activates the lectin pathway of complement involving MASP-2. We sought to evaluate the significance of MBL deficiency (O/O genotypes) and insufficiency (O/O plus XA/O genotypes), as well as MASP-2 deficiency (D105G mutation), in the susceptibility to and severity and outcome of CAP in adults....

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Source: Blood Weekly (2008-09-25)

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