Bone Research

New findings reported from Weizmann Institute of Science, Department of Molecular Genetics describe advances in bone research

Published in Blood Weekly, October 2nd, 2008

A new study, 'Protein tyrosine phosphatases in osteoclast differentiation, adhesion, and bone resorption,' is now available. "Osteoclasts are large cells derived from the monocyte-macrophage hematopoietic cell lineage. Their primary function is to degrade bone in various physiological contexts," researchers in Rehovot, Israel report.

"Osteoclasts adhere to bone via podosomes, specialized adhesion structures whose structure and subcellular organization are affected by mechanical contact of the cell with bone matrix. Ample evidence indicates that reversible tyrosine phosphorylation of podosomal proteins plays a major role in determining the organization and dynamics of...

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Source: Blood Weekly (2008-10-02)

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