Ischemia

Researchers from RWTH Aachen University publish new studies and findings in the area of ischemia

Published in Blood Weekly, October 16th, 2008

"The nitrite anion is reduced to nitric oxide (NO center dot) as oxygen tension decreases. Whereas this pathway modulates hypoxic NO center dot signaling and mitochondrial respiration and limits myocardial infarction in mammalian species, the pathways to nitrite bioactivation remain uncertain," investigators in Aachen, Germany report.

"Studies suggest that hemoglobin and myoglobin may subserve a fundamental physiological function as hypoxia dependent nitrite reductases. Using myoglobin wild-type ((+/+)) and knockout ((-/-)) mice, we here test the central role of myoglobin as a functional nitrite reductase that regulates hypoxic NO center dot generation, controls...

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Source: Blood Weekly (2008-10-16)

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