Life Sciences

New data from University of Kansas illuminate research in life sciences

Published in Blood Weekly, October 16th, 2008

According to a study from the United States, "Thiobenzamide (TB) is a potent hepatotoxin in rats, causing dose-dependent hyperbilirubinemia, steatosis, and centrolobular necrosis. These effects arise subsequent to and appear to result from the covalent binding of the iminosulfinic acid metabolite of TB to cellular proteins and phosphatidylethanolamine lipids [Jiet al. (2007) Chem. Res. Toxicol. 20, 701-708]."

"To better understand the relationship between the protein covalent binding and the toxicity of TB, we investigated the chemistry of the adduction process and the identity of the target proteins. Cytosolic and microsomal proteins isolated from the livers of rats...

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Source: Blood Weekly (2008-10-16)

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