Hypertension
Recent studies from Mario Negri Institute for Pharmacological Research add new data to hypertension
Published in Blood Weekly, October 16th, 2008
New research, 'Polymorphisms of EDNRB, ATG, and ACE genes in salt-sensitive hypertension,' is the subject of a report. According to a study from Bergamo, Italy, "Almost 50% of hypertensive individuals manifest blood pressure changes in response to salt depletion or repletion and are termed 'salt sensitive' (SS). Blunted activity of the endothelin (ET) system and the renin-angiotensin-aldosterone system (RAAS) have been reported as possible mechanisms contributing to salt sensitivity."
"Data are available that endothelin receptor subtype B (ETBR)-deficient rats develop salt-sensitive hypertension when fed a high-salt diet. Whether the ETBR gene (EDNRB) is involved in...
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Source: Blood Weekly (2008-10-16)
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