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Research from North Carolina State University broadens understanding of blood pressure

Published in Blood Weekly, October 16th, 2008

"The complexity of mathematical models describing the cardiovascular system has grown in recent years to more accurately account for physiological dynamics. To aid in model validation and design, classical deterministic sensitivity analysis is performed on the cardiovascular model first presented by Olufsen, Tran, Ottesen, Ellwein, Lipsitz and Novak (J Appl Physiol 99(4): 1523 - 1537, 2005)," scientists writing in the journal Cardiovascular Engineering report.

"This model uses 11 differential state equations with 52 parameters to predict arterial blood flow and blood pressure. The relative sensitivity solutions of the model state equations with respect to each of...

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