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Cancer

Studies conducted at Chicago Medical Center on cancer recently published

Published in Blood Weekly, October 23rd, 2008

According to recent research published in the journal Cancer Research, "The discovery of gene fusion mutations, particularly in leukemia, has consistently identified new cancer pathways and led to molecular diagnostic assays and molecular-targeted chemotherapies for cancer patients. Here, we report our discovery of a novel CREB3L2-PPAR gamma fusion mutation in thyroid carcinoma with t(3;7)(p25;q34), showing that a family of somatic PPAR gamma fusion mutations exist in thyroid cancer."

"The CREB3L2-PPAR gamma fusion encodes a CREB3L2-PPAR gamma fusion protein that is composed of the transactivation domain of CREB3L2 and all functional domains of PPAR gamma 1....

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