Stem Cell Research
Study data from H. Hauser et al provide new insights into stem cell research
Published in Blood Weekly, October 23rd, 2008
"A single nucleotide polymorphism (SNP) responsible for lactase persistence (LCT -13910C >T) changes intestinal microflora. Considering the influence of bacterial microflora on various immune effects, we tested DNA from 111 recipients/donors and analyzed whether this SNP interferes with survival and the incidence of acute graft-versushost disease (aGVHD) after allogeneic hematopoetic stem cell tranplantations (HSCT)," investigators in Linz, Austria report.
"Median overall survival (OS) was significantly longer when donors had a CC genotype (not reached after 133 vs 11.1 months, P=.004). Multivariate analysis identified a donor T allele (hazard ratio 2.63, 95%...
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Source: Blood Weekly (2008-10-23)
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