Leukemia Therapy
Reports summarize leukemia therapy study results from University of Texas, M.D. Anderson Cancer Center
Published in Blood Weekly, October 23rd, 2008
Investigators publish new data in the report 'Altered gene expression in busulfan-resistant human myeloid leukemia.' "Busulfan (Bu) resistance is a major obstacle to hematopoietic stem cell transplantation (HSCT) of patients with chronic or acute myelogenous leukemia (CML or AML). We used gene expression analysis to identify cellular factors underlying Bu resistance," researchers in the United States report.
"Two Bu-resistant leukemia cell lines were established, characterized and analyzed for differentially expressed genes. The CML B5/Bu250(6) cells are 4.5-fold more resistant to Bu than their parental B5 cells. The AML KBM3/Bu250(6) cells are 4.0-fold more...
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Source: Blood Weekly (2008-10-23)
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