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Cancer Vaccines

Researchers from Baylor College of Medicine, College of Medicine provide details of new studies and findings in the area of cancer vaccines

Published in Blood Weekly, October 23rd, 2008

According to a study from the United States, "The cancer testis antigen (CTA) preferentially expressed antigen of melanoma (PRAME) is overexpressed in many hematologic malignancies, including chronic myeloid leukemia (CML). The sensitivity of CIVIL to donor lymphocyte infusion after allogeneic stem cell transplantation suggests this tumor can be highly susceptible to cellular immunotherapy targeted to tumor associated antigens."

"We therefore tested whether functional PRAME-specific cytotoxic T lymphocytes (PRAME CTLs) could be generated and expanded from healthy donors and CML patients, or whether the limited immunogenicity of this CTA coupled with tumor-associated...

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