Bone Marrow Failure

On the trail of a targeted therapy for blood cancers: Exploring protein critical to blood cell development

Published in Blood Weekly, October 30th, 2008

Investigators from the Herman B Wells Center for Pediatric Research at the Indiana University School of Medicine are focusing on a family of blood proteins that they hope holds a key to decreasing the toxic effects of chemotherapy in children and adults.

Their findings may one day help in the development of targeted therapies for leukemia, multiple myeloma and other cancers of the blood.

The researchers, led by Kristin T. Chun, Ph.D., assistant professor of pediatrics and of biochemistry and molecular biology, studied how the cullin family of proteins affects the degradation of proteins that control the development of blood cells. Their work was...

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Source: Blood Weekly (2008-10-30)

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