Leukemia
Research on leukemia described by scientists at Tufts University
Published in Blood Weekly, November 6th, 2008
According to recent research from the United States, "Transformation by Abelson murine leukemia virus (Ab-MLV) is a multistep process in which growth-stimulatory signals from the v-Abl oncoprotein and growth-suppressive signals from the p19(Arf)-p53 tumor suppressor pathway oppose each other and influence the outcome of infection. The process involves a proliferative phase during which highly viable primary transformants expand, followed by a period of marked apoptosis (called ''crisis'') that is dependent on the presence of P19(Arf) and p53; rare cells that survive this phase emerge as fully transformed and malignant."
"To understand the way in which v-Abl expression...
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Source: Blood Weekly (2008-11-06)
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