Life Sciences

Reports on life sciences findings from Y.C. Lin and co-researchers provide new insights

Published in Blood Weekly, November 6th, 2008

"Human c-Myb proto-oncogene is highly expressed in hematopoietic progenitors as well as leukemia and certain solid tumor. However, the regulatory mechanisms of its expression and biological functions remain largely unclear," scientists writing in the journal Molecular Biology and Evolution report.

"Recently, c-Myb has been shown to be targeted by microRNA-150 (miR-150) which thereby controls B cell differentiation in mice. In this study, we demonstrated that c-Myb is an evolutionary conserved target of miR-150 in human and zebrafish, using reporter assays. Ectopic expression of miR-150 in breast cancer and leukemic cells repressed endogenous c-Myb at both...

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Source: Blood Weekly (2008-11-06)

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