Lymphocytic Leukemia
Study findings from V.F. Tumilasci et al broaden understanding of lymphocytic leukemia
Published in Blood Weekly, November 6th, 2008
"Chronic lymphocytic leukemia (CLL) is characterized by clonal accumulation of CD5(+) CD19(+) B lymphocytes that are arrested in the G,VG, phase of the cell cycle and fail to undergo apoptosis because of overexpression of the antiapoptotic B-cell CLL/lymphoma 2 (BCL-2) protein. Oncolytic viruses, such as vesicular stomatitis virus (VSV), have emerged as potential anticancer agents that selectively target and kill malignant cells via the intrinsic mitochondrial pathway," investigators in Montreal, Canada report.
"Although primary CLL cells are largely resistant to VSV oncolysis, we postulated that targeting the apoptotic pathway via inhibition of BCL-2 may sensitize CLL...
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Source: Blood Weekly (2008-11-06)
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