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Sepsis

Research on sepsis discussed by scientists at University of Amsterdam

Published in Blood Weekly, November 6th, 2008

"Purpose of review An impaired function of the protein C pathway plays a central role in the pathogenesis of sepsis. Administration of human recombinant activated protein C (Xigris) may restore the dysfunctional anticoagulant mechanism and may simultaneously modulate the pro-inflammatory response," scientists in Netherlands report.

"Initial clinical studies with activated protein C in patients with sepsis showed a reduction of 28-day mortality. However, subsequent studies did cast some doubt on the efficacy and also the safety of this treatment. Recent findings A number of randomized controlled clinical studies confirm beneficial effects of activated protein C in...

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