Stem Cell Research

Reports outline stem cell research study findings from E.R. Meng and colleagues

Published in Blood Weekly, November 6th, 2008

"Extracellular high mobility group box 1 (HMGB1) is a novel cytokine that takes part in the processes of inflammation, tissue damage and regeneration. Mesenchymal stem cells (MSCs) are adult stem cells characterized by their inherently suppressive activities on inflammative and allo-immune reactions," investigators in Beijing, People's Republic of China report.

"In the present study, we have addressed whether HMGB1 could affect the biological properties of human bone marrow MSCs. Transwell experiments showed that HMGB1 induced MSC migration and this effect could not be hampered by a blocking antibody against the receptor for advanced glycation end products (RAGE). MSCs...

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Source: Blood Weekly (2008-11-06)

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