Stem Cell Research

Researchers from Harvard University describe findings in stem cell research

Published in Blood Weekly, November 6th, 2008

"Stem cell population size is highly regulated across species and tissue types, and alterations are associated with premature tissue failure or cancer. We assessed whether the tumor suppressor and mediator of cell contact inhibition Nf2/merlin plays a role in governing the hematopoietic stem cell pool by stem cell-autonomous or niche-determined processes," scientists in the United States report.

"Hematopoietic stem cells in Nf2-deficient mice were increased in number and demonstrated a marked shift in location to the circulation. These changes were entirely dependent on changes in the microenvironment, with a marked increase in trabecular bone and marrow vascularity...

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Source: Blood Weekly (2008-11-06)

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