Sepsis

Researchers from Technical University of Munich report recent findings in sepsis

Published in Blood Weekly, November 6th, 2008

According to recent research published in the Journal of Experimental Medicine, "Gram-negative bacterial infection is a major cause of sepsis and septic shock. An important inducer of inflammation underlying both syndromes is the cellular recognition of bacterial products through pattern recognition receptors (PRRs), including Toll-like receptors (TLRs)."

"We identified a novel antagonistic mAb (named 1A6) that recognizes the extracellular portion of the TLR4-MD-2 complex. If applied to mice before infection with clinical isolates of Salmonella enterica or Escherichia coli and subsequent antibiotic therapy, 1A6 prevented otherwise fatal shock, whereas application...

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Source: Blood Weekly (2008-11-06)

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