Liquid Chromatography
Research on liquid chromatography discussed by T. Legrand and co-researchers
Published in Blood Weekly, November 6th, 2008
A new study, 'Determination of ketamine and norketamine in plasma by micro-liquid chromatography-mass spectrometry,' is now available. "A sensitive method of determination of ketamine and norketamine by micro-liquid chromatography/mass spectrometry was developed as part of a clinical trial in a pediatric population. Compounds were extracted from 100 microl plasma samples using solid-phase extraction on Oasis MCX cartridges," researchers in Paris, France report.
"Separation was achieved on a C18 micro-column with a mobile phase composed of formic acid 0.1% and acetonitrile (90/10, v/v). Detection of ketamine, norketamine and their internal standard norketamine D4 was...
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Source: Blood Weekly (2008-11-06)
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