Bone Marrow

Findings from S. Okazaki and co-authors provide new insights into bone marrow

Published in Blood Weekly, November 6th, 2008

According to recent research published in the journal Stem Cells and Development, "Previously, we have shown that liver allografts obtained from the fetus or young mice are accepted when bone marrow cells (BMCs) from adult mice of the same strain are co-grafted. However, for practical clinical use, it is more convenient to obtain both BMCs and liver from the same adult donors."

"C57BL/6 mice were irradiated with a single high-dose irradiation or two low-dose irradiations and injected with donor BALB/c (8 weeks old) BMCs intravenously (IV-BMT) or directly into the recipient BM cavity (IBM-BMT). Liver tissues taken from the same donor were, on the same day,...

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Source: Blood Weekly (2008-11-06)

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