Burkitt Lymphoma
Scientists at Children's Hospital target Burkitt lymphoma
Published in Blood Weekly, November 6th, 2008
"Here we demonstrate that Puma deletion in the E mu-Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that similar to 75% of E mu-Myc lymphomas naturally select against Puma protein expression. Furthermore, approximately 40% of primary human Burkitt lymphomas fail to express detectable levels of PUMA and in some tumors this is associated with DNA methylation. Burkitt lymphoma cell lines phenocopy the primary tumors with respect to DNA...
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Source: Blood Weekly (2008-11-06)
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