Acute Promyelocytic Leukemia

Findings in acute promyelocytic leukemia reported from Tor Vergata University

Published in Blood Weekly, November 20th, 2008

"Therapy-related acute promyelocytic leukemia (t-APL) with t(15;17) translocation is a well-recognized complication of cancer treatment with agents targeting topoisomerase II. However, cases are emerging after mitoxantrone therapy for multiple sclerosis (MS)," researchers in Rome, Italy report.

"Analysis of 12 cases of mitoxantrone-related t-APL in MS patients revealed an altered distribution of chromosome 15 breakpoints versus de novo APL, biased toward disruption within PML intron 6 (11 of 12, 92% vs 622 of 1022, 61%: P = .035). Despite this intron spanning approximately 1 kb, breakpoints in 5 mitoxantrone-treated patients fell within an 8-bp region (1482- 9)...

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Source: Blood Weekly (2008-11-20)

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