Whitehead Institute for Biomedical Research
New clue emerges for cellular damage in Huntington's disease
Published in Blood Weekly, December 4th, 2008
CAMBRIDGE, Mass. (November 17, 2008) – "Huntington's disease presents an ideal vantage point to study neurodegenerative disease, because we know the misfolded protein that's responsible," says Martin Duennwald, formerly a postdoctoral researcher in the lab of Whitehead Member Susan Lindquist. "But we don't understand how this protein causes cellular damage and death for the neurons that are affected."
In a study published in Genes & Development online on November 17, however, Duennwald and Lindquist report the discovery of a mechanism driven by the misfolded proteins that could be one early trigger for cell death.
In the U.S., about 1 in 20,000...
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Source: Blood Weekly (2008-12-04)
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