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Portal Hypertension

New data from Medical University of Lublin illuminate research in portal hypertension

Published in Blood Weekly, December 18th, 2008

According to recent research from Lublin, Poland, "In last years significant progress in recognizing mechanisms of portal hypertension pathophysiology was done. However, Some unclear topics in this disease still exist."

"Portal hypertension is primarily Caused by the increase in resistance to portal outflow and secondly by an increase in splanchnic blood flow. Portal hypertension is associated with changes in the intrahepatic, systemic, and portosystemic collateral circulation. Alterations in vasoreactivity (vasodilation and vasoconstriction) play a central role in the pathophysiology of portal hypertension by contributing to increased intrahepatic resistance,...

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