Angiogenesis
Scientists at Duke University, Department of Medicine publish research in angiogenesis
Published in Blood Weekly, December 25th, 2008
Scientists discuss in 'Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC' new findings in angiogenesis. "Transforming growth factor beta (TGF-beta) signals through two distinct pathways to regulate endothelial cell proliferation, migration, and angiogenesis, the ALK-1/Smad 1/5/8 and ALK-5/Smad2/3 pathways. Endoglin is a co-receptor predominantly expressed in endothelial cells that participates in TGFbeta-mediated signaling with ALK-1 and ALK-5 and regulates critical aspects of cellular and biological responses," scientists writing in the Journal of Biological Chemistry...
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Source: Blood Weekly (2008-12-25)
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