Stem Cell Research
New stem cell research from University of Paris discussed
Published in Blood Weekly, December 25th, 2008
New investigation results, 'BCR-ABL induces opposite phenotypes in murine ES cells according to STAT3 activation levels,' are detailed in a study published in Cellular Signalling. According to a study from Villejuif, France, "The mechanisms by which p210-BCR-ABL determines hematopoietic stem cells fate remain poorly understood. To better understand the behavior of BCR-ABL in pluripotent stem cells, we previously developed a murine embryonic stem (ES) cell model transformed by p210-BCR-ABL and reported that BCR-ABL activates STAT3, a major protein involved in ES cells self-renewal, which leads specifically to inhibition of ES cells differentiation."
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Source: Blood Weekly (2008-12-25)
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