Cardiomyopathy
New findings from China Pharmaceutical University in the area of cardiomyopathy published
Published in Blood Weekly, January 1st, 2009
"Dissociation of FKBP12.6 from RyR2 is considered as an important molecular event resulting in calcium leak and an increased risk in arrhythmogenesis. We hypothesized that augmented ventricular fibrillation (VF) on reperfusion of rat cardiomyopathy induced by L-thyroxin may result from elevated diastolic Ca2+ levels due to dissociation (downregulation) of FKBP12.6 and upregulation of endothelin (ET-1) signaling pathway," scientists writing in the International Journal of Cardiology report.
"Rats were treated with L-thyroxin (0.4 mg/kg, s.c.) for 10 days. Dajisentan (CPU0213), a dual endothelin receptor antagonist ( 100 mg/kg p.o.), or propranolol was administered...
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Source: Blood Weekly (2009-01-01)
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