Dengue Fever
Study results from University of London, Medical Department broaden understanding of dengue fever
Published in Blood Weekly, January 15th, 2009
"Severe dengue virus (DV) infections can cause the life-threatening condition dengue hemorrhagic fever, which is characterized by a severe plasma leak, thrombocytopenia, hemorrhage, and, in severe cases, circulatory collapse and death. There is now much evidence that pre-existing immunity to DV can enhance disease when an individual becomes infected on a second or sequential occasion," scientists writing in the Journal of Immunology report.
"It has been shown that in contrast to infected dendritic cells (DC), noninfected bystander DC underwent maturation in dengue infection. In this study, we show that TNF-alpha and type I IFN contribute to the maturation of...
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Source: Blood Weekly (2009-01-15)
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