Lymphocytic Leukemia

Research on lymphocytic leukemia published by A. Sainzperez et al

Published in Blood Weekly, January 15th, 2009

According to recent research published in the Journal of Immunology, "Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of long-lived monoclonal B Cells mostly arrested at the G,VG, phase of the cell cycle. CLL cells strongly express intracellular melanoma differentiation-associated gene-7 (MDA7)/IL-24."

"However, adenovirus-delivered MDA7 was reported to be cytotoxic in several tumor cell lines. We report herein that rIL-24 alone had no effect; however, sequential incubation with rIL-2 and rIL-24 reduced thymidine incorporation by 50% and induced apoptosis of CLL cells in S and G(2)/M phases of the cell cycle, but not of normal adult blood...

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Source: Blood Weekly (2009-01-15)

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