Stem Cell Research

Research from Erasmus University in stem cell research provides new insights

Published in Blood Weekly, January 22nd, 2009

"Mesenchymal stem cells (MSC) have multilineage differentiation and immunomodulatory capacities and are potentially useful for therapeutic applications, such as tissue regeneration and control of alloreactivity. MSC are present in most tissues including the transplantable organs," researchers in Rotterdam, Netherlands report.

"It is therefore unavoidable that MSC will be exposed to immunosuppressive drugs in a clinical transplantation setting. The molecular targets of these drugs are expressed in MSC, but the effect of their inhibition on MSC functioning is unknown. MSC were isolated and expanded from heart tissue and the effects of the calcineurin inhibitor tacrolimus,...

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Source: Blood Weekly (2009-01-22)

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