Blood Substitutes

Research on blood substitutes described by scientists at Ohio State University

Published in Blood Weekly, January 22nd, 2009

According to recent research published in the journal Bioconjugate Chemistry, "In this work, we describe the synthesis and characterization of a novel glycosylated hemoglobin (Hb) with high oxygen affinity as a potential Hb-based oxygen carrier. Site-selective glycosylation of bovine Hb was achieved by conjugating a lactose derivative to Cys 93 on the beta subunit of Hb."

"LC-MS analysis indicates that the reaction was quantitative, with no unmodified Hb present in the reaction product. The glycosylation site was identified by chymotrypsin digestion of the glycosylated bovine Hb followed with LC-MS/MS and from the X-ray crystal structure of the glycosylated Hb....

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Source: Blood Weekly (2009-01-22)

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