Apoptosis

University of Otago reports research in apoptosis

Published in Blood Weekly, January 22nd, 2009

According to recent research from Christchurch, New Zealand, "Isothiocyanates are a class of phytochemicals able to induce apoptosis in numerous cells including Jurkat T-lymphoma cells overexpressing the oncoprotein Bcl-2. To test if isothiocyanates are also effective against other anti-apoptotic members of the Bcl-2 family we generated Jurkat cells stably overexpressing Bcl-X-L."

"Phenethyl isothiocyanate (PEITC) was cytotoxic to these cells, with an LD50 ranging from 9 to 18 mc M depending on the level of Bcl-X-L expression. Apoptosis induction in response to PEITC was confirmed by caspase activation and phosphatidylserine exposure. Isothiocyanates specifically target...

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Source: Blood Weekly (2009-01-22)

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