Coagulation
Study results from J. Bird and colleagues update understanding of coagulation
Published in Blood Weekly, January 29th, 2009
"To report a case in which the anticoagulation effect of warfarin appeared to be potentiated by torsemide, possibly due to an interference of metabolism through competition for the CYP2C9 isoenzyme and protein-binding displacement of warfarin. SUMMARY: A 43-year-old Hispanic female with congestive heart failure, hypothyroidism, anemia, atrial fibrillation, and a mitral mechanical valve replacement was effectively anticoagulated with a target international normalized ratio (INR) of 2.5-3.5 on a warfarin regimen of 50-52.5 mg/wk," scientists in the United States report.
"One week following the initiation of torsemide 40 mg in the morning and 20 mg in the afternoon, a...
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Source: Blood Weekly (2009-01-29)
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