Leukemia

Scientists at University of Pittsburgh discuss research in leukemia

Published in Blood Weekly, January 29th, 2009

According to recent research published in the journal Cancer Research, "Expression of the high-risk human papillomavirus (HPV-16) E7 oncoprotein extends the life span of primary human keratinocytes and partially restores telomere length in the absence of telomerase. The molecular basis of this activity is incompletely understood."

"Here, we show that HPV-16 E7 induces an increased formation of alternative lengthening of telomeres (AI,T)-associated promyelocytic leukemia bodies (APBs) in early passage primary human keratinocytes as well as HPV-negative tumor cells. This activity was found to require sequences of HPV-16 E7 involved in degradation of the...

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Source: Blood Weekly (2009-01-29)

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